Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists
1990
A series of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid esters and amides containing a basic azacyclo- or azabicycloalkyl moiety has been synthesized and evaluated for 5-HT 3 antagonistic activity in a radioligand binding assay ([ 3 H]ICS 205930) and in the 5-HT-induced von Bezold-Jarisch reflex in the rat
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