Clinical significance hyperimmunoglobulin Е syndrome

Heterogeneity of immuno-inflammatory diseases pathogenesis has been revealed with high concentration of immunoglobulin E in some nosological forms, which requires further study. Aim. To analyze literature data, to present retrospective analysis and personal observations of patients with high concentration of IgE in the blood. Material and methods. In 7 patients with autoinflammatory diseases and 130 rheumatic patients, examined earlier, the analysis of IgE concentration has been carried out by radio-immune method or by immune-enzyme analysis. Results. Clinical observations of patients with derated immunoglobulin E syndrome are represented. The possibilities of genetic analysis and the connection of the derated IgE syndrome with vascular dysfunctions in rheumatic diseases are discussed. Conclusion. When making diagnosis is complicated in patients with inflammatory syndrome of unclear etiology and high IgE concentration in the blood, it is necessary to keep in mind the autoinflammatory genesis of this process. Further study of the role of the derated immunoglobulin E syndrome in pathogenesis is required.