Ins Herz des sekretorischen Pfades: Stress mobilisiert Ionenkanäle

Arginine-based ER localization signals are peptide sorting motifs recognized by the COPI vesicular coat. They have a well-characterized role in the quality control of multimeric membrane protein assembly. Recent evidence from cardiac myocytes implies that these peptide-sorting motifs can mediate Golgi storage of membrane protein cargo, which can translocate to the cell surface upon phosphorylation of the motif. Cardiac ATPsensitive potassium channels are thus deployed to the surface of ventricular cardiomyocytes during the fight-or-flight response.