Immunoprophylaxis in Guinea Pigs with Mycobacterium indicus pranii (Mw) in Combination with Standard Chemotherapy of M. tuberculosis Infection ImprovesLung Pathology
2016
Tuberculosis continues to be a major global health problem. BCG (Bacillus Calmette–Guerin) has been used as a
vaccine to control tuberculosis, however, the protective value of the vaccine has been reported be highly variable
across different populations. During the last three decades, several workers have investigated the potential of
protective efficacy of Mycobacterium indicus pranii (MIP or Mw) against mycobacterial infections (leprosy and
tuberculosis) which has been used as an immunoprophylactic tool and also as an adjunct to chemotherapy. The
present study, reports the beneficial effect of prior immunization with MIP in terms of improvement in
histopathological findings and reduction of bacterial burden, as augmenter to the effects of chemotherapy in
experimental tuberculosis.
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