Sustained Remission Achieved With ATRA and Chemotherapy in Second Relapse of Acute Promyelocytic Leukemia in Down Syndrome

Children with Down syndrome (DS) are at an increased risk of developing acute leukemia. Acute myeloid leukemia predominates among DS children below 4 years of age but acute promyelocytic leukemia (APL) has rarely been reported in DS. Acute myeloid leukemia in DS is extremely sensitive to treatment b