Prevalence and clinical relevance of low levels of Pru p 3 specific IgE in patients with peach sensitization

Background The peach Lipid Transfer Protein (LTP), Pru p 3, is considered to be a major allergen in peach allergy, but sensitization to it is almost always present in LTP-syndrome. Thus, detection of Pru p 3 specific IgE (sIgE) is frequent in routine peach and/or LTP allergy diagnosis. ImmunoCAP is one of the most frequent immunoassays for specific IgE detection, with a 0.1kU/L detection limit, although 0.35kU/L has traditionally been adopted as the positivity cutoff. The aim was to analyze the prevalence and clinical relevance of low levels of Pru p 3 sIgE in a cohort of patients diagnosed of peach sensitization.