Synthesis of 1‐Deazaadenosine Analogues of (2′ → 5′) ApApA.

Abstract Synthesis of (2′ → 5′)ApApA analogues containing 1-deazaadenosine at different positions is described (32–34). The approach used the phosphotrieer methodology in solution and utilized 3′-O-benzoylated derivatives of the N6-protected 5′-O-monomethoxytrityl-1-deazaadenosine as starting material. Dedicated to Prof. Y. Mizuno on the occasion of his 75th birthday