Dexamethasone and cyclosporin A do not inhibit interleukin-15 expression in the human lung carcinoma cell line A549

INTRODUCTION The cytokine IL-15 is a member of the "four-helix-bundle" family of cytokines [1, 2] which is functionally similar to IL-2 in in vitro and in vivo systems although it has no sequence similarities with IL-2. IL-15 has been shown to act on T cells, B cells, NK cells and others [for review see 3, 4]. IL-15-mediated signal transduction involves the gammac-chain of the IL-2 receptor; in addition the beta-chain of the IL-2 [...]