Protective effects of crude polysaccharides from Radix Pseudostellariae on rat experimental cardiopulmonary injury induced by acute myocardial infarction in vivo

Objective:To study the protective effects of crude polysaccharides from Radix Pseudostellariae(RP) on rat experimental cardiopulmonary injury induced by acute myocardial infarction in vivo.Methods:The cardiopulmonary injury were reproduced after 4 weeks by ligatured the left coronary artery in rats.The cardiac function was assayed by hemodynamics,heart index,ventriculus sinister index and lung index were detected by weight,pathologic change was checked out by histophathology,and cardiac infarction size was assayed by image analysis system.Resutls:After 4 weeks of operation,cardiac function was disturbed according to the results of hemodynamics.Cardiac and lung index,and cardiac infarction size was significantly increased in model group.Results of histopathology confirmed that cardiac myocyte decreased,cardiac fibrosis increased,inflammatory cell infiltration,and pulmonary congestion and edema,which indicate the model was succeed.After continued administrating crude polysaccharides from Radix Pseudostellariae 4 weeks it can remarkable ameliorate cardiac function,decrease the cardiac and lung index,and attenuate the heart failure pathological change.Conclusion:Crude polysaccharides from Radix Pseudostellariae can alleviate rat cardiopulmonary injury induced by acute myocardial infarction,the present research provide the pharmacological base of bioactivity ingredients for replenishing qi to invigorate the spleen and promoting the production of body fluid and nourishing the lung.