Drug-Induced Anaphylaxis in Latin American Countries

RESULTS: There were 1005 patients evaluated for possible drug hypersensitivity reactions during the study interval, and 264 (26.3%) met criteria for DIA. DIA was more frequent in adults and in elderly females (N [ 129 [76.6%] and N [ 30 [75%], respectively) compared with children and/or adolescents (N [ 21 [42.9%], P < .01). Severe DIA was less frequent with underlying asthma (N [ 22 vs 35 [38.6% vs 61.4%], P < .05) or atopy (N [ 62 vs 71 [43% vs 59% ], P < .01). Nonsteroidal anti-inflammatory drugs (NSAIDs) (N [ 178 [57.8%]), beta-lactam antibiotics (N [ 44 [14.3%]), and other antibiotics (N [ 16 [5.2%]) were the most frequently implicated drug classes. Anaphylaxis was rated as severe in N [ 133 (50.4%) and anaphylactic shock (AS) was present in N [ 90 (34.1%). Epinephrine was only