Palladium‐Catalyzed Amination of C‐5 Bromoimidazo[2,1‐b][1,3,4]thiadiazoles.

A new and efficient palladium-catalyzed amination of imidazo[2,1-b][1,3,4]thiadiazole at the C-5 position under microwave irradiation is reported. The reactivity toward bromine release at the C-5 position was investigated, and palladium-catalyzed cross-coupling conditions were optimized. A wide range of amines was employed to examine the scope and limitations of the method. To complete this methodological study, the influence of the nature and the positions of additional imidazo[2,1-b][1,3,4]thiadiazole substitutions was investigated.