Новые иммунологические методы диагностики аутоиммунного полиэндокринного синдрома 1-го типа (первый опыт в России)

3 , E. HUSBI 3 This study was designed to ascertain the role of anti-interferon (IFN)-ω and -α2 antibodies (AB) in diagnostics of type 1 autoim- mune polyglandular syndrome (APS-1) and evaluate specificity and sensitivity of the HEK-Blue cells method used to detect these antibodies. The study included 34 patients presenting with APS-1 and 21 patients with focal alopecia. All 100% of the patients with APS-1 ehxhibited high titers of anti IFN-ω antibodies; 97% of them had anti IFN-a 2 antibodies. These antibodies were not found in the patients with focal alopecia. It is concluded that the measurement of anti IFN-α and α 2 antibodies with the use of HEK-Blue cells is a highly specific and sensitive method for diagnostics of APS-1.