Comparison of 2 diets with either 25 or 10 energy% gelatin on energy expenditure, substrate balances and appetite profile

Summary Background & aims Increasing the protein content of a diet results in increased satiety and energy expenditure. It is unknown to what extent gelatin has such effects. We compared satiety and energy expenditure in subjects on 2 single-protein diets with either 25% or 10% of energy (En%) from gelatin. Methods During 36 h in a respiration chamber, 24 healthy subjects (BMI 22.4 ± 2.4 kg/m 2 ; age 25 ± 7 y) received subject specific isoenergetic diets: 25En% (25/20/55En%-protein/fat/carbohydrate) and 10En% gelatin diet (10/35/55En%-protein/fat/carbohydrate), in a randomised crossover design. Three days before, subjects consumed a diet with similar macronutrient composition at home. Results The 25En% compared with the 10En% gelatin diet resulted in a 2.1 ± 1.0% higher 24-h energy expenditure (9.20 ± 0.23 vs. 9.01 ± 0.23 MJ/d, P P P P P P Conclusions In the short-term a 25En% compared with a 10En% gelatin diet boosts energy expenditure, promotes a positive protein and negative fat balance, and reduces hunger.