Targeting high transcriptional control activity of long mononucleotide A-T repeats in cancer by Argonaute 1

Abstract Epigenetic regulatory changes alter the gene regulation function of DNA repeat elements in cancer and consequently promote malignant phenotypes. Some short tandem repeat sequences, distributed throughout the human genome, can play a role as cis -regulatory elements of the genes. Distributions of tandem long (≥10) and short (