Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands

Kenneth J. Wildonger,Ronald W. Ratcliffe,Ralph T. Mosley,Milton L. Hammond,Elizabeth T. Birzin,Susan P. Rohrer

Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands

2006

Kenneth J. Wildonger
Ronald W. Ratcliffe
Ralph T. Mosley
Milton L. Hammond
Elizabeth T. Birzin
Susan P. Rohrer

A series of 2–9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERβ and were highly selective.

Keywords:

Side chain
Steric effects
Organic chemistry
Enone
Ligand (biochemistry)
Estrogen receptor beta
Molecular model
Biochemistry
Ligand
Chemistry
Phenols
Chemical synthesis
Stereochemistry

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