Development of a simple and non-invasive method for measuring cerebral blood flow using Technetium-99m compounds and spectral analysis

Cerebral blood flow (CBF) can be quantified using the brain perfusion index (BPI), determined from radionuclide angiographic data generated by 99mTc-HMPAO or 99mTc-ECD. The BPI is generally calculated using graphical analysis (GA). However, the BPI values obtained by GA (BPIG) are not in proportion to CBF. In this study, we measured BPI using spectral analysis (SA) (BPIS), and compared them with BPIG to investigate the carefulness of BPIS.