Antibiotic Adjustment in Continuous Renal Replacement Therapy

Abstract The management of infection in the intensive care unit represents an imperative challenge for critical care clinicians. At present, antibiotic dosing regimens are derived from studies on healthy volunteers and do not account for these major differences in drug prescriptions. The chapter summarizes the pharmacokinetic/pharmacodynamics relationship changes in antimicrobial agents resulting from the typical homeostatic disturbance or altered end-organ function of the critical illness. The focus is on how the renal clearance alterations or continuous renal replacement therapy may affect individual antimicrobial dosage and dosing interval of the antimicrobial agents.