Chiral tetraazamacrocycles having four pendant-arms.

A chiral tetraazamacrocycle 9 having four pendant-arms was synthesized by repeating ring opening of an Ns-aziridine with secondary amines, followed by macrocyclization. The structure of 9 has been determined by single crystal X-ray diffraction analysis and NMR studies. Sugar-hybrid molecules 12a−12f were synthesized based on the scaffold 9. NMR study showed that 12a−12f keep the similar conformation as 9 in solution.