von Hippel-Lindau Disease-Associated Hemangioblastomas Are Derived from Embryologic Multipotent Cells

Deric M. Park,Zhengping Zhuang,Ling Chen,Nicholas Szerlip,Irina Maric,Jie Li,Tae-Sung Sohn,Stephanie H. Kim,Irina A. Lubensky,Alexander O. Vortmeyer,Griffin P. Rodgers,Edward H. Oldfield,Russell R. Lonser

von Hippel-Lindau Disease-Associated Hemangioblastomas Are Derived from Embryologic Multipotent Cells

2007

Deric M. Park
Zhengping Zhuang
Ling Chen
Nicholas Szerlip
Irina Maric
Jie Li
Tae-Sung Sohn
Stephanie H. Kim
Irina A. Lubensky
Alexander O. Vortmeyer
Griffin P. Rodgers
Edward H. Oldfield
Russell R. Lonser

Background To determine the origin of the neoplastic cell in central nervous system (CNS) hemangioblastomas in von Hippel-Lindau disease (VHL) and its role in tumor formation and distribution, we characterized and differentiated neoplastic cells from hemangioblastomas removed from VHL patients.

Keywords:

Hemangioblastoma
Cellular differentiation
Stromal cell
Von Hippel–Lindau disease
Multipotent Stem Cell
Cerebellar Neoplasm
Central nervous system
Hematopoietic stem cell
Medicine
Pathology
neoplastic cell
Hemangioblast

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