Clinical outcomes of contrast-induced nephropathy in patients undergoing percutaneous coronary intervention : A prospective, multicenter, randomized study to analyze the effect of hydration and acetylcysteine

Abstract Backgrounds The potential role of hydration in prevention of contrast-induced nephropathy (CIN) still remains to be unclear. Methods Nine-hundred and thirty-six patients scheduled for percutaneous coronary intervention (PCI) were enrolled into the present study, and divided into normal (serum creatinine Results The incidence of CIN was more commonly in abnormal group that in normal group (6.52% vs. 37.68%, p p =0.0007), contrast volume≥320 ml (OR 3.26, 95% CL 2.14 to 7.58, p =0.01), diabetes mellitus (OR 9.86, 95% CL 5.38 to 31.67, p p Conclusion Patients with CIN and preexisting renal insufficiency had worse clinical outcomes. Hydration with 0.45% sodium chloride alone had no potential effect on the occurrence of CIN in patients with normal renal function. Combination of hydration with ATLS could reduce the incidence of CIN in patients at high risk.