Assignment of resonances for ‘acute-phase’ glycoproteins in high resolution proton NMR spectra of human blood plasma
1987
Abstract Broad resonances at 2.04 and 2.08 ppm in 500 MHz Hahn spin-echo 1 H NMR spectra of human blood plasma are assigned to the N -acetyl groups of mobile carbohydrate side-chains (largely N -acetylglucosamine and N -acetylneuraminic acid) of glycoproteins such as α 1 ,-acid glycoprotein. Their intensities in spin-echo spectra correlate with clinical conditions in which an elevation of the level of ‘acute-phase’ glycoproteins is expected, and so may be of value in the study of certain diseases.
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