A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase
2003
Abstract Horner–Emmons reaction of phosphonate amides with aldehydes leads to generation of o -substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure–activity relationships (SAR) for soluble guanylyl cyclase (sGC) activator drug discovery.
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