Repeated chemotherapy cycles produced progressively worse and enduring impairments in the sleep–wake profile of hospitalized breast cancer patients

ABSTRACTCross-sectional studies, conducted previously, reported disruption of the sleep–wake rhythms of cancer patients on chemotherapy. Although few studies highlighted the effect of hospitalization on sleep, no data were obtained on the effects of longitudinal repeated chronotherapy cycles on sleep pattern of cancer patients. In this study, using the two-factor repeated-measures design, we attempted to assess longitudinally the quality and pattern in sleep–wake behavior of breast cancer in- and outpatients, who received multiple cycles of chemotherapy. We randomly selected the patients from the Regional Cancer Center, Dr. B.R. Ambedkar Memorial Hospital, Raipur, India. We used wrist-worn actigraphs to record the sleep–wake pattern both objectively and subjectively. Additionally, we administered Pittsburgh Sleep Quality Index questionnaire to each patient. Results revealed statistically significant effects of chemotherapy with and without hospitalization mostly on all objective [total sleep time, sleep o...