Antisense Bcl-2 oligonucleotide uptake in human transitional cell carcinoma.

Brian J. Duggan,Finbarr E. Cotter,John D. Kelly,Peter Hamilton,Kevin McCallion,Denis Paul Harkin,Tom Gardiner,Neil Anderson,Patrick F. Keane,Samuel R. Johnston,Kate E. Williamson

Antisense Bcl-2 oligonucleotide uptake in human transitional cell carcinoma.

2001

Brian J. Duggan
Finbarr E. Cotter
John D. Kelly
Peter Hamilton
Kevin McCallion
Denis Paul Harkin
Tom Gardiner
Neil Anderson
Patrick F. Keane
Samuel R. Johnston
Kate E. Williamson

Objectives: Antisense oligonucleotides (AO) downregulate Bcl–2 protein expression in various tumours if good target cell uptake is achieved. In this study, uptake of FITC labelled A

Keywords:

Oligonucleotide
Apoptosis
Cell
Pathology
Sense (molecular biology)
Downregulation and upregulation
Transitional cell carcinoma
Medicine
Flow cytometry
Cell culture
Cytometry
Ex vivo

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