The Lipid-regulating Effects of Atorvastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia

To investigate the effect of atorvastatin on lipid metabolism in type 2 elder diabetes patients with hyperlipidemia, 26 patients with type 2 elder diabetes complicated with hyperlipidemia were treated with atorvastatin (10 mg/d) for 8 weeks. The serum triglyceride (TG), high density protein cholesterol (HDL-C) and low density protein cholesterol (LDL-C) were measured before and after the treatment. Meanwhile, the non-denaturing polyacrylamide gradient gel electrophoresis was used for detection of small-sized LDL(SLDL). Our results showed that TG dropped from 4.88±0. 72 mmol/L to 2.65±0.32 mmol/L; HDL-C was increased from 0. 85±0. 31 mmol/L to 1.28±0. 29 mmol/L; LDL-C was declined from 3. 71±2.98 mmol/L to 2.10± 1.22 mmol/L, sLDL-A was increased from (42.49 ± 8. 1) % to (53.27 ± 7.5) %; LDL B was decreased from ( 57.91 ± 8.1) % to (46.73±7.5 %) (P＜0.05). The level of blood glucose was not changed at the end of 8th week. It is concluded that atorvastatin has satisfactory lipid-regulating effects on type 2 elder diabetes patients with hyperlipidemia.