Evaluation of antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of Chrysanthemum fontanesii flowers and leaves extracts

Abstract This study was aimed to evaluate the antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of n -butanol extracts from leaves and flowers of Chrysanthemum fontanesii . β-carotene-linoleic acid, Galvinoxyl radical (GOR), ABTS, hydroxyl radical, reducing power, CUPRAC, O-phenanthroline and metal chelating assays were used to evaluate antioxidant capacity of the extracts. The extracts showed good antioxidant activity and were a good source of phenolics and flavonoids. The enzyme inhibitory activity of the extracts was investigated against key enzymes involved in neurodegenerative [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE], type 2 diabetes (α-glucosidase) and skin (tyrosinase) disorders. In the cholinesterase inhibitory assays, the extracts of leaves and flowers exhibited weak activity against AChE and BChE. n -butanol extracts from leaves and flowers displayed high inhibitory activity against α-glucosidase, showing potential properties against type 2 diabetes. Whereas for anti-tyrosinase activity, only flowers extract showed good inhibitory activity. Furthermore the leaves and flowers extracts showed high photoprotective activity with the sun protection factor (SPF) value: 38.96 ± 0.26 and 38.66 ± 0.68, respectively. Our study on C. fontanesii open new perspectives for developing novel health-promoting agents by pharmaceutical, cosmetics and food industries.