Effect of laboratory parameters on prognostic value in patients with newly diagnosed brain metastases: Analysis of 1,207 cases.

e13034 Background: We investigated the prognostic value of laboratory parameters in a large cohort of brain metastasis (BM) patients. Methods: 1207 Patients treated for newly diagnosed BM from extracranial solid cancers (472/1207 (39.1%) lung cancer; 270/1207 (22.4%) breast cancer; 164/1207 (13.6%) melanoma; 121/1207 (10.0%) renal cell carcinoma; 101/1207 (8.4%) colorectal cancer; 79/1207 (6.5%) other primary tumor) were included in the analysis. Clinical characteristics including survival times and laboratory parameters at diagnosis of BM were retrieved by chart review. Laboratory parameters with significant impact on overall survival from diagnosis of BM in univariate analysis were entered in multivariate analysis together with known prognostic factors including primary tumor type, graded prognostic assessment (GPA) class and treatment modality for BM. Results: At univariate survival analysis, hemoglobin level < lower limit of normal (LLN), platelet count < LLN, leukocyte count < LLN, serum albumin leve...