Early Carotid Atherosclerosis and Hepatic Lipase-514 C/T Polymorphism: A Study in Hyperalphalipoproteinemic Individuals

Objective: Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and has a key role in reverse cholesterol transport and atherosclerosis. The aim of this study was to evaluate the effects of HL -514C/T polymorphism on sub-clinical and established carotid atherosclerotic in hyperalphalipoproteinemic and control individuals. Methods: One hundred and sixty nine asymptomatic individuals (aged 47 ± 16 years), 71 hyperalphalipopro-teinemic (Hyper-A, HDL-C = 68mg/dL) and 98 controls (CTL, HDL-C Objetivo: La Lipasa Hepatica (HL) esta implicada en el metabolismo de las lipoproteinas distintas y desempena un papel en el transporte inverso del colesterol y la aterosclerosis. El objetivo de este estudio fue evaluar los efectos del polimorfismo HL-514 C/T en la aterosclerosis carotidea subclinica en los individuos e hiperalfalipoproteinemicos y controles establecidos. Metodos: Ciento sesenta y nueve sujetos asintomaticos (edad 47 ± 16 anos), 71 hiperalfalipoproteinemicos (Hyper-A, HDL-C = 68mg/dL) y 98 controles (CTL, HDL-C