Studies on the mechanism of chlorpromazine protection against Brucella endotoxin in mice.

Abstract The administration of chlorpromazine is associated with a significant prolongation of survival time of intact or adrenalectomized mice challenged with lethal doses of Brucella endotoxin. This protective effect of CPZ does not appear to be critically dependent upon the corticoid-stimulating, sedative, adrenolytic, antihistaminic, and hypothermic effects of the drug. The possible neurogenic mechanisms of the CPZ protection against endotoxin are discussed.