The relationship of systolic pulmonary arterial pressure with pulmonary function test and the fractional exhaled nitric oxide level in Kyrgyz population

Aim: to investigate the relationship of systolic pulmonary arterial pressure (SPAP) with pulmonary functional test (PFT) indices and the fractional exhaled nitric oxide level (FeNO) in ethnic Kyrgyz. Methods and Materials: 551 ethnic Kyrgyz were investigated (mean age - 47.6 ± 14.15 years, mean body mass index (BMI) - 28.1 ± 5.5 kg/m2): 460 women (83.49%) and 91 men (16.51%). The study included a clinical examination, an anthropometry (height and weight), 2D and Doppler echocardiography, PFT, and measurement of FeNO. SPAP was measured non-invasively by echocardiography. Statistic analysis was performed to measure the correlation SPAP with PFT indices and the FeNO levels. Results: the results are presented in the table Mean Analysis of the results revealed a significant, though weak negative correlation between SPAP and FVC (r = -0.211; p = 0.000), FEV1 (r = -0.231; p = 0.000). However, there were no correlation between the FeNO levels and SPAP. Conclusion: negative correlation was found between SPAP and FVC and FEV1 in ethnic Kyrgyz.