The Efficacy of Piper crocatum Extract in Reducing the Symptoms of Physiological Fluor Albus

Leukorrhea or increased vaginal discharge is a common complaint female adolescences. Piper crocatum extract or red betel vine extract is known to have antiseptic and antibacterial effect. The aim of the study was to investigate the antiseptic effect of Piper crocatum extract soap in the reduction of symptoms of physiologic leukorrhea in the external genitalia area. This was an open, comparative, 2 parallel groups, clinical trial. Thirty five out of 52 screened subjects met the selection criteria and finished the clinical trial. In the evaluation of Candida sp, Streptococcus sp. and Staphylococcus epidermidis on the product-smeared or control-smeared perineum, it was found that the colony of Candida sp. and Streptococcus epidermidis is less on the productsmeared perineum than in the control-smeared perineum. Streptococcus sp. was not found in both product-smeared or control-smeared perineum. Piper crocatum extract soap reduced the total score (skin redness, unpleasant odor, score of vaginal discharge, edema and squammation) from 1,40 to 0,20 after one week. From the analysis of the subjects’ diary card it was found that Piper crocatum extract soap reduced the score of vaginal discharge from 0,65 (Day 1) to 0,24 (Day 8). There is no adverse event recorded except for one event of squammation. Keywords: red betel vine extract, leucorrhea, Candida sp., Staphylococcus epidermidis, Streptococcus sp