A new trend of targeted therapy in non-small cell lung cancer: EML4-ALK fusion gene

Individualized treatment in non-small cell lung cancer has reached a consensus today and targeted therapy is one of the important parts of it.EML4-ALK is a new molecular subtype discovered in non-small cell lung cancer cells.The high detection rate in patients who are Asian,female,with never or light smoking history,adenocarcinoma and the good curative effect of PF-02341066,a kind of ALK inhibitor in period Ⅰ clinical trials,make EML4-ALK be another targeted therapeutic target for non-small cell lung cancer. Key words: Non-small cell lung cancer; EML4-ALK fusion gene; Targeted therapy