An experimental study of safflower yellow pigment on cerebrocellular apoptosis in senile model mice

Objective:To investigate the effect of safflower yellow pigment on cerebrocellular apoptosis and correlate factor in senile model mice. Method: We established senile model mice with D-galactose. The safflower yellow pigment was extracted by means of big aperture resin. The effects of various dosage of safflower yellow pigment on cerebro cellalar apoptosis and Bcl-2 were observed. Result:Safflower yellow pigment could obviously decrease cerebrocellular apoptosis and enhanced the levels of Bcl-2. Conclusion: Safflower yellow pigment is an active component of carthamin tinctorius in delayed senescence, it can inhibit apoptosis starting and obviously decrease cerebrocellular apoptosis.