Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes
1996
1
The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in rats was studied.
2
A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine.
3
Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone.
4
Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes.
5
These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.
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