Synthesis of 2,6-Anhydro-3-deoxy-5-O-phosphono-3-tetradecanamido-4-O-(( R)-3-(tetradecanoyloxy)tetradecanoyl)-D-glycero-D-ido-heptonic Acid as a New Potent Endotoxin Antagonist and Its Dimeric Analogue.
2010
A pyran carboxylic acid analogue of GLA-60 (14) and its dimeric analogue 18 were synthesized in a stereocontrolled manner. Compound 14 showed strong LPS-antagonistic activity.
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