Clinical effect of amiodarone on atrial fibrillation after heart valve replacement: a Meta-analysis

Objective To investigate the clinical effect of amiodarone on patients with atrial fibrillation after heart valve replacement, and to provide reference basis for improving the efficacy of patients with atrial fibrillation after heart valve replacement. Methods The PubMed, Web of Science, WILEY medical and nursing discipline database, Cochrane Library, CNKI, Wanfang database, VIP database and China Biology Medicine disc were searched by computer. Randomized controlled trials (RCTs) about amiodarone treating patients with atrial fibrillation after heart valve replacement were searched from the establishment of the database to 24th September , 2019. After two people's independent literature screening and literature quality evaluation, relevant data were extracted and quantitative comprehensive analysis was conducted with Revman 5.3 software. Results A total of 7 articles were included, including 6 Chinese articles and 1 English article. There were 710 patients in total, including 363 cases in the experimental group and 347 cases in the control group. Quantitative synthesis was performed with Revman 5.3 software, and the results showed that amiodarone treatment for atrial fibrillation after valve replacement could improve the recovery rate of atrial fibrillation (RR=1.36, 95%CI: 1.20-1.54, P<0.05) . The rate of sinus rhythm maintenance was increased (RR=1.41, 95%CI: 1.16-1.72, P=0.002) , the ICU monitoring time was shortened (MD=-1.09, 95%CI: -1.32--0.86, P<0.05) , and the total days in hospital was reduced (MD=-3.92, 95%CI: -4.25--3.59, P<0.05) . Conclusions Amiodarone treatment for atrial fibrillation after valve replacement can improve the recovery rate of atrial fibrillation and the rate of sinus rhythm maintenance, reduce the ICU monitoring time and the total days in hospital, which is worthy of clinical application. Key words: Meta-analysis; Amiodarone; Kedalong; Heart valve disease; Heart surgery; Atrial fibrillation; Atrial fibrillation; Treatment effect