Hippocampal neurons code individual memory episodes in humans

The hippocampus is an essential hub for episodic memory processing. However, how human hippocampal single neurons code multi-feature associations remains unknown. Here, we provide evidence that individual neurons code discrete memory episodes, which we term Episode Specific Neurons (ESNs). These ESNs do not reflect the coding of a particular feature in the episode (i.e., concept or time). Instead, they code for the conjunction of the different elements that make up the episode.