The effect observation of statins in treatment of chronic kidney disease

Objective To observe the clinical efficacy of therapy with statins in treatment of chronic kidney disease,and to explore the non-statin lipid-lowering effect on prevention and treatment of chronic kidney disease.Methods 100 cases of patients with chronic kidney disease as the research object,were divided into the observation group and the control group,50cases in the control group,while 50 cases in the observation group.Above conventional treatment,the observation group with simvastatin treatment.The two groups were respectively observed lipids(triglyceri de,cholesterol),renal function(blood urea nitrogen,serum creatinine,endogenous creatinine clearance rate) and 24 hour urinary protein quantitative before and after one and ten months treatment,then compared them between the two groups.Results After 1 months of treatment,the index of 24 hours urinary protein between the two groups were decreased significantly(P 0.05),while the other indexes had no obvious change.While after 10 months of treatment,in the observation group,the index of triglyceride,cholesterol,24 hour urinary protein quantity,blood urea nitrogen,serum creatinine were significantly lower than that before treatment and the control group(P 0.05),and CCr was significantly higher than that in control group and before treatment(P 0.05). Conclusion The the clinical efficacy for kidney protection in observation group treatment was significantly better than the control group,and the results had shown that statins protect the function of kidney,this protective effect for non lipid-lowering dependent.