Pathophysiology of asthma: From endotype to phenotype

Background: SNPs could affect the outcome of asthma severity : in MPO, −463G>A (rs2333227) ; angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism (287 base pairs, on chromosome 17q23, intron 16(rs1799752); type 1 Angiotensin II receptor -AGTR1 1166A/C (rs5186); iNOS intron 20 (IVS20 + 524 G>A-rs944722); β-2 adrenergic receptor gene (ADRB2) Arg16Gly (rs1042713) and Gln27Glu (rs1042714). Methods: Asthmatics compared with controls ; polymorphisms analyzed by PCR and PCR-RFLP .Control of asthma assessed by (ACQ7 and PAQLQ). Statistical analysis performed with PASW 18, establishing a significance level of p A the genotypes carrying allele A are more frequent among asthmatics and genotypes carrying allele G among controls(p 0.05).For iNOS, it could be a risk factor for asthma, being allele G and GG genotype more prevalent in asthmatics(p 0,05); in Arg16Gly polymorphism the genotype carrying allele G is more frequent among males (p