Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process.

Richard Schlemmer,Thilo Spruß,Günther Bernhardt,Helmut Schönenberger

Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part 1: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplat inum (II) inhibits this process.

2000

Richard Schlemmer
Thilo Spruß
Günther Bernhardt
Helmut Schönenberger

The MXT-M-3.2 breast cancer implanted into female B6D2F1 mice accelerates the growth of an identical second tumor. This process is inhibited by [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II). The possible modes of action of this compound as a biological response modifier are discussed.

Keywords:

Cancer
Breast cancer
Biochemistry
Mechanism of action
Meso compound
Chemistry
Biological activity
Diamine
Ethylenediamine
Stereochemistry
Ligand

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