Phyto-Hormetins in a Clinical Setting

Abstract Apart from hormetic effects of exercise or calorie restriction, phyto-hormetins from bulk and/or nanosized forms of antioxidant plant foods and herbs can help prevent and/or reverse disease in a clinical setting. Diseases benefiting from this approach include infections, cardiovascular conditions, diabetes mellitus, arthritis, various cancers, and neurodegenerative diseases such as Alzheimer’s dementia and Parkinson’s disease, most of which reflect degenerative processes during aging. Plant-derived hormetins include resveratrol (grapes), curcumin (turmeric), rosmarinic acid (rosemary), and quercetin (apples, onions), as well as various herbal remedies. Low dose natural agents modulate functioning of the cell stress response network (CSRN) including redox pathways and heat shock proteins that protect the body from damage by higher levels of toxins and other cross-reactive stressors. The CSRN is a key homeodynamic component of the body as a complex adaptive system. Overall phyto-hormetins offer an emerging therapeutic strategy for supporting disease prevention and treatment while promoting healthier longevity.