An apical MRCK-driven morphogenetic pathway controls epithelial polarity

Ceniz Zihni,Evi Vlassaks,Stephen J. Terry,Jeremy G. Carlton,Thomas Leung,Michael F. Olson,Franck Pichaud,Maria S. Balda,Karl Matter

An apical MRCK-driven morphogenetic pathway controls epithelial polarity

2017

Ceniz Zihni
Evi Vlassaks
Stephen J. Terry
Jeremy G. Carlton
Thomas Leung
Michael F. Olson
Franck Pichaud
Maria S. Balda
Karl Matter

Zihni et al. discover a role for Cdc42–MRCK signalling in establishing contractility at the apical pole, which in turn controls epithelial polarity in mammalian cells and Drosophila photoreceptors.

Keywords:

Cell biology
Myosin
Epithelial polarity
Contractility
Cell polarity
Morphogenesis
Biology
Anatomy
Apical constriction

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