S1233 Evaluation of Long Pentraxin Ptx3 for the Inflammation Marker in the Patients with Ulcerative Colitis

Backgrounds & Aims: CRP, short pentraxin C-reactive protein, is often used in the evaluation of inflammatory status in ulcerative colitis (UC). However, usually serum CRP level does not increase in active UC because the short pentraxin CRP is produced mainly by the liver in response to interleukin (IL)-6, as well as IL-6 level is not so high in patients with UC. Pentraxin-3 (PTX3) is a prototypic long pentraxin mainly by dendritic cells, macrophages and endothelial cells in response to primary inflammatory stimuli. We reported increased plasma PTX3 concentration in active inflammatory bowel diseases (Kato S et al. Dig Dis Sci 2007 in press). The aims of this study were to investigate the usefulness of plasma PTX3 concentration as an diagnositic and therapeutic marker for patients with UC. Materials & Methods: Plasma PTX3 levels were examined in 46 UC patients by sandwitch ELISA. Mayo Scoring system was used to evaluate disease activity in UC patients. Plasma PTX3 concentrations were evaluated for disease type and clinical course. Sensitivity, specificity and accuracywere evaluated Results: Plasma PTX3 concentration was decreased after treatment for UC. For disease type, plasma PTX3 concentration of total colitis , left side colitis and proctitis type were 8.05+-4.03, 9.22+-5.35 and 3.55+-1.91(concentration of of total colitis , left side colitis vs proctitis type, p<0.05). Serum CRP concentration of of total colitis , left side colitis and proctitis type were 2.01+-3.39, 1.1+-2.71 and 0.11+-0.1. For clinical course, plasma PTX3 concentration of one attack only , relapse-remitting and chronic continuous type were 3.79+-2.52, 8.06+-5.02 and 6.82+-2.93. Serum CRP concentration of one attack only , relapse-remitting and chronic continuous type were 0.12+-0.084, 1.83+-3.43 and 0.57+1.00. Sensitivity, specificity and accuracy of plasma PTX3 concentration against disease activity were 74%, 92% and 83% in UC patients. However, sensitivity, specificity and accuracy of serum CRP concentration were 39%, 100% and 70%. Conclusions: Plasma PTX3 concentration is a good diagnostic and therapeutic marker in patients with UC.