Determination of the Pharmacokinetics and Tissue Distribution of Methyl 3,4-Dihydroxybenzoate (MDHB) in Mice Using Liquid Chromatography-Tandem Mass Spectrometry

Jia-Hui Wang,Song-Hui Hu,Ji Yan Su,Jun-Ping Pan,Xiang-Nan Mi,Hai Ju Geng,Wei Zhang,Liang Cai,Chao‑Fen Su,Ai-Hua Hong,Huan‑Min Luo

Determination of the Pharmacokinetics and Tissue Distribution of Methyl 3,4-Dihydroxybenzoate (MDHB) in Mice Using Liquid Chromatography-Tandem Mass Spectrometry

2019

Jia-Hui Wang
Song-Hui Hu
Ji Yan Su
Jun-Ping Pan
Xiang-Nan Mi
Hai Ju Geng
Wei Zhang
Liang Cai
Chao‑Fen Su
Ai-Hua Hong
Huan‑Min Luo

Background and Objectives Methyl 3,4-dihydroxybenzoate (MDHB) has the potential to prevent neurodegenerative diseases (NDDs). The present work aims to reveal the pharmacokinetics and tissue distribution characteristics of MDHB.

Keywords:

Biochemistry
Liquid chromatography–mass spectrometry
Chemistry
Chromatography
Pharmacokinetics
tissue distribution

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