The preparation and microbiological evaluation of the inhibitory effects of some acrylic acid derivatives.

Abstract The following acrylic acid derivatives have been prepared and microbiologically evaluated as possible inhibitors of the growth of lactobacilli; indoleacrylic acid, β-(2-quinolyl)-, β-(3-quinolyl)-, β-(4-quinolyl) acrylic acids, cinnamic acid, p -hydroxycinnamic acid, p -dimethylaminocinnamic acid, p -diethylaminocinnamic acid, thienylacrylic acid, furylacrylic acid, and α-ethylacrylic acid. The utilization of tryptophan by Leuconostoc mesenteroides P-60 and Lactobacillus arabinosus was inhibited by the isomeric quinolylacrylic acid derivatives as well as by indoleacrylic acid. With this latter compound and the β-(3-quinolyl)acrylic acid, competitive inhibition was shown. p -Hydroxycinnamic acid inhibited the utilization of phenylalanine and tyrosine by all the organisms tested. At similar concentrations neither cinnamic acid nor phenol exerted any inhibitory effect. The effects of all inhibitors could be at least partially reversed by the addition of larger quantities of the corresponding amino acids.