Synthesis of oxirane from quinones against T. cruzi

Chagas disease is an endemic disease caused by T. cruzi. Approximately 16 to 18 million people are infected and 50000 individuals die every year from this disease. Only two drugs have been used since the 70s: nifurtimox and benznidazole. Several synthetic substances continue to be reported in the literature, 2a,b but none of them become a new drug for a effective treatment. Our group synthesized many oxirane derivatives from quinones which showed a potent trypanocidal activity . The objective of this study is to synthesize new oxirane derivatives and evaluate them against T. cruzi.