The impact of lens choice in the relief of contact lens related symptoms and ocular surface findings

Abstract Purpose : The aim of this study was to compare the efficacy of hioxofilcon A and omafilcon A soft contact lenses for the reduction of signs and symptoms of contact lens related dryness among contact lens wearers who presented with symptoms and signs at baseline. Methods : Forty dry eye subjects, 37 females and 3 males, were enrolled in this prospective, single-center, randomized, contra-lateral, cross-over study. Subjects were randomly dispensed hioxifilcon A and omafilcon A lenses for contra-lateral eyes. Lenses were worn daily wear for 3 months; for 6 weeks (2-week lens replacement) then lens types were crossed over to opposite eyes for 6 more weeks. Clinical examinations took place at baseline, 1 and 6 weeks in each cycle. Ocular surface signs and symptoms were evaluated by self-administered questionnaire. Results : Compared to baseline symptoms with habitual lenses, dryness, discomfort, and blurry vision were reported at a lower frequency and intensity with both test lens types ( p p p Conclusion : Symptoms and ocular surface staining associated with contact lens related dryness can be significantly alleviated by the use of hioxofilcon A or omafilcon A lenses, which yielded similar findings in this study.