The association of obstructive sleep apnoea with Epworth Sleepiness Score and metabolic syndrome in patients on a Barrett's Oesophagus registry

Introduction Barrett9s Esophagus (BE), a condition of intestinal metaplasia of the oesophagus is associated with an increased risk of esophageal adenocarcinoma (EAC). Patients with OSA share risk factors with patients with BE including: obesity, reflux, older age, and male gender. Patients added to a detailed clinical database in the previous 12 months were invited to participate in this study. Methods Male patients (18 - 70 yrs old) completed the following screening procedures: Anthropometric measurements; Sleep assessment - sleep questionnaires with Epworth Score (ESS); Polysomnography (AASM criteria); Prevalence of Metabolic Syndrome (MetS) was estimated with the International Diabetes Federation criteria. Results Of the first 40 subjects screened 32 (80%) had significant OSA (AHI ›5) with 22 (53%) falling in the moderate to severe category. Subjects with OSA tended to be 10 years older (p Conclusions Subclinical OSA was common in these patients with BE in the absence of significant daytime symptoms of excessive sleepiness. The severity of OSA correlated with the severity of MetS. Studies will be designed to assess the benefit of CPAP intervention in these patients.