Functional perfusion and blood-brain barrier permeability images in the diagnosis of cerebral tumors by angio CT

Abstract We performed rapid sequential CT scanning following iv injection of a bolus of contrast medium and generated three functional images relating to intravascular circulation time (rABCT) vascular volume ( V v ) density and blood-brain barrier (BBB) unidirectional constant uptake rate ( K i ), respectively. This was accomplished by calculating the first mathematical moment of the monitored time-density curves about the injection time and from the multiple time graph analysis described by Patlack and co-workers. A satisfactory resolution was achieved, allowing separate appreciation of changes in rABCT both in large vessels and in tissue small vessels. Combined evaluation of rABCT and V v images allowed us to differentiate between tumors.