The stereoselective total synthesis of PF1163A

Abstract A stereoselective total synthesis of 13-membered macrocycle PF1163A, an antifungal agent, has been accomplished for the first time starting from d -xylose. This approach involves a diastereoselective allylation of lactal ether, 3a reductive ring opening of tetrahydrofuran ring, 3b asymmetric methylation reaction, Yamaguchi esterification, and ring closing metathesis as key steps.